Founded in 2007, Lotus Separations provides purification services to clients from small start-ups to top five US pharmaceutical companies. Our industry-leading expertise and robust method development can fulfil all your chiral and achiral separation needs, on milligram to kilo scales.
Lotus has unmatched expertise in separations procedures, offering screenings on traditional and cutting-edge stationary phases
Excellent instrumentation
Lotus employs an impressive lineup of analytical and preparative SFC and HPLC instruments with UV and MS detection, as well as state-of-the-art NMR methods and HRMS
We work on jobs big and small
Lotus collaborators range from Fortune 100 pharmaceutical companies to small academic research labs, working on sample quantites from milligram to kilogram scales
Woman-owned business
Lotus is a certified woman-owned business, committed to pursuing equity in the sciences
A Message from our CEO
Christina Kraml
Founder and CEO
Here at Lotus, we serve our clients with a personal touch, tailoring our process to meet your individual needs—all while while delivering the fastest results with the highest quality.
Our Services
Preparative Separations
Technologies
Supercritical Fluid Chromatography (SFC) with over 25 preparative stationary phases, chiral and achiral
High Performance Liquid Chromatography (HPLC) with all modes of separations including RPLC, NPLC, HILIC , ANP, HIC, IEX, and SEC
UV/VIS and/or Mass-directed fraction collections
High-throughput mass-directed well plate–to–well plate sub-milligram purifications
Metabolites, impurities, or biomarker isolations
Purity enhancements of drug substances or intermediates
Scales and Quantities
Research Scale: milligrams to hundred grams
Production Scale: multi-grams to kilograms
Analytical Separations
Method Development
Chiral separations
Achiral separations
Applications
Enantiomeric ratio determination
Diastereomeric ratio determination
Chemical purity by RPLC/MS
Extended Analytical Services
Analytical Research
Chemical Stability
Enantiomer stability and chiral interconversion kinetics
Solubility studies, including pH/pI-dependent aqueous solubility
Compound Characterization
Quantitative analysis by SFC or LC with UV, MS, and/or CAD
Structural analysis by LC/MS/MS, Accurate MS, and NMR
Absolute stereochemistry determination
Our Locations
Newark, DE
Princeton, NJ
New Castle, DE
Testimonials
Sir David MacMillan
2021 Nobel Laureate
“The Lotus team are real experts. They know their stuff and we love working with them!”
Kevin Hunt
CSO, Vanqua Bio
“Great in quality, timeframe, and consistent on all scales.”
Contact
Ask for a quote, more about our services, or anything else!
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